An indolamine neurotransmitter on of the subgroup of mono-amine/amines also called 5-HT or 5-hydroxytryptamine.Its chemical name is 5-HT. It is discovered by Jouvet. It is produced by raphe nuclei near the mid brain and project axons to the cerebral cortex.
According to dictionary of biology "serotonin acts on muscles and nerves".It controls dilation and constriction of blood vessels and effects gestro intestinal tracks/region. ts also related to depression.
Bio SynthesisThe precursor of 5-HT is the amines acid tryptophan.An enzyme converts tryptophan to 5-HTP (5-hydroxytryptophan). Another enzyme converts 5-HTP to 5-HT (serotonin).
Figure
Tryptophan_____ 5-HTP______ 5-HT.
Behavioral Effects
- 5-HT plays a role in the regulation of mood.
- It controls the eating, sleep and arousal activities.
- It controls and regulate pain.
- It is also involved in dreaming.
- Studies indicate that suicidal depression is related to 5-HT level.
The neurons are found in the nine cluster.The most of the clusters are located in the raphe nuclei of the mid brain pones and medulla.The two most important clusters are found in the dorsal and medulla.The two most important clusters are found in the dorsal and medial raphe nuclei.
Like Nor-epinephrine, 5-HT is released from varicosities. Investigators have identified nine different types of serotonin receptors.
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