Acetylcholine is the primary NTM secreted by efferent axons of the central nervous system (CNS). Ach is also found at the majority of synapse where one nerve cell needs another nerve and produced Ach.These synapse are said to be acetylcholinergic synapse. They from the para-sympathetic nervous system.This chemical substance is stores in the viscles near the synapse and released when a nerve impulse arrives.
Bio Synthesis
It is composed of two components.
1. Choline
A substance derived from the breakdown of lipids.
2. Acetate (Acetic Acid)
Acetate transferred from a molecule CoA (Acetyl-CoA) which is produced by mitochondria.
Figure
CoA+Acetate____ ChAT (Choline Aceytl transferase)____ Acetylcholine (Ach)
Behavioral Effects
- The acytlcholinergic neurons located in the dorsal lateral pons are responsible of REM (Rapid Eye Movement).
- The neurons which are located in the basal fore-brain are involved in learning especially in perceptual learning.
- Muscular movement is accomplished by the release of Ach.
- The neurons which are located in the medial septum control the electrical rhythms of hyppocmpus, formate the kind of memories.
Nicotinic Receptors
It is stimulated by nicotine (A drug found in tobacco leaves).
Muscrainic Receptors
It is stimulated by muscrainic (A drug found in the poison mushroom) (Amanita muscaria).
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